Projects

Reference: MFA/2022/014. Title: Desarrollo de agentes de imagen molecular
para PET/MR basados en materiales híbridos tipo MOF con ácidos nucleicos. Funding institution: Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana. Convocatoria: Programa de Materiales con funcionalidades avanzadas para la nueva transformación tecnológica. PI: J. Gonzalez Garcia (Universidad de Valencia). Start and end date: 30/06/2022 – 29/06/2025.

Research lines

(1) Chemical Biology of Non-Canonical Nucleic Acid Structures.
Nucleic acids (DNA and RNA) can adopt several structures in which the double helical DNA (canonical DNA) is the most common at cellular level. Nevertheless, non-canonical structures can form transiently during biological processes such as replication or RNA transcription. Our team is devoted to understand the roles of these non-canonical DNA/RNA structures in cells using a bottom-up multimodal approach of synthesis of small molecules, biophysical characterization of the interaction and cell evaluation to assess the biological mechanism.

(2) Applications of Metal Complexes in Chemical Biology
Metal ions are essential components in the biological systems and control their functions, in particular iron, zinc and copper. Metal complexes can be synthetically obtained in the wet-lab with interesting and unusual properties and thereof, we are interested in the development of metallic complexes for imaging and therapeutic applications.

Teaching

MRs’s final project
(Master’s degree in Molecular Nanoscience and Nanotechnology, Institute of Molecular Science, University of Valencia)

Techniques for the study of bioinorganic interactions
(Master´s degree in Experimental Techniques in Chemistry, University of Valencia)

Chemistry II
(Degree in in Industrial Electronic Engineering, University of Valencia)